STEP

The master protocol defines the core principles of the design and operation for all sites and all domains of the STEP platform. The Master Protocol may be amended but it is anticipated that such amendments will be infrequent.

Domain-Specific Appendices contain only that information specific to those interventions within a domain and not already specified in the master protocol. As such, the Master Protocol does not include information about the intervention(s) that will be evaluated within the platform, but rather provides the framework on which multiple different interventions, within domains, can exist within this trial.

To determine subsets of AIS patients within 24 hours of last known well, currently not treated with EVT according to guidelines, who do or do not benefit from EVT compared to Medical Management by having better functional outcome.

NOTE: As of 3/11/25 we will EXCLUDE tandem occlusions and exclude known ICAD.  

ARPEGGIO and ID IMR

Call Yazmin 412-913-8424 or Paul 412-225-5656 at any time!

For stroke patient with anterior LVO is going to IR or being considered for IR when you are on stroke call.  There is significant overlap in patient eligibility between ARPEGGIO and ID IMR.   We have a script ready to share with patients and can engage the appropriate CRCs accordingly.  You do NOT need to know the I/E criteria provided below, we are just sharing for convenience sake: