Precision Medicine in Neurocritical Care

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Precision Medicine in Neurocritical Care

Precision medicine is “an innovative approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person” and has expanded from oncology to many other fields of medicine.1 Most clinical trials testing neurocritical care treatments have not been based on principles of precision medicine. Rather, they have used a “one-size-fits-all” approach. This has left us with largely neutral results regarding blood pressure (BP) management or surgical intervention for intracerebral hemorrhage, intracranial pressure (ICP) management in traumatic brain injury (TBI), and neuroprotection for ischemic stroke, TBI, and spinal cord injury.

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Delayed cerebral ischemia - Journal Club 10/18/18

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Delayed cerebral ischemia - Journal Club 10/18/18

Delayed cerebral ischemia (DCI) is a major cause of morbidity and mortality from aneurysmal subarachnoid hemorrhage (aSAH), occurring in 30% of patients.1 Historically, symptomatic large artery vasospasm was thought the be the primary mechanism leading to DCI, but there is increasing evidence that many other processes contribute, including impaired cerebral autoregulation, cortical spreading depolarizations, and microvascular spasm and thrombosis.2 The early identification of patients at risk for DCI is an essential task for neurointensivists.

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Post Cardiac Arrest Syndrome

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Post Cardiac Arrest Syndrome

Pathophysiological (who rounds with me knowns is one of my fav words) processes triggered by the whole-body ischemia-reperfusion response that occurs during cardiac arrest and subsequent restoration of systemic circulation.

Why it matters ? Hypoxic Ischemic Encephalopathy ( HIE) is the overall endpoint result of the post- cardiac arrest syndrome .This topic is particularly relevant to neurointsvisits because 1) they can influence it by managing  the post-cardiorespiratory arrest syndrome 2) they lead neuroprognostication.

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