In 2002, two landmark clinical trials published back-to-back in the New England Journal of Medicine (Bernard and HACA), building upon animal models that showed a neuroprotective benefit to hypothermia after cardiac arrest, set the bar for post-cardiac arrest care in the new millennium. Practice patterns changed rapidly as intensivists and hospital systems attempted to replicate their results, with greater than 50% of their patients in the 33C hypothermia arm of each trial achieving a good neurological outcome.